Publications of Jennifer Munkert



Kreis W and Munkert J (2019) Exploiting enzyme promiscuity to shape plant specialized metabolism. Journal of Experimental Botany 70(5): 1435-1445 (DOI:10.1093/jxb/erz025)

Boffa L, Munkert J, Melo Ottoni F, Schneider NFZ, Ramos GS, Kreis W, de Andrade SF, Dias de Souza JF, Braga FC, Alves RJ, Pádua RM, Simões CMO (2019) Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives. European Journal of Medicinal Chemistry 167: 546-561 (DOI:10.1016/j.ejmech.2019.01.076)

Gomes ER, Novais MVM, Silva IT, Barros ALB, Leite EA, Munkert J, Frade ACM, Cassali GD, Braga FC, Pádua RM, Oliveira MC (2018) Long-circulating and fusogenic liposomes loaded with a glucoevatromomoside derivative induce potent antitumor response. Biomedicine & Pharmacotherapy 108: 1152-1161 (DOI: 10.1016/j.biopha.2018.09.109)

Schmidt K, Petersen J, Munkert J, Egerer-Sieber C, Hornig M, Muller YA, Kreis W (2018) PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism. Phytochemistry 156:9-19 (DOI: 10.1016/j.phytochem.2018.08.012)

Silva IT, Munkert J, Nolte E, Schneider NFZ, Rocha SC, Ramos ACP, Kreis W, Braga FC, Pádua RM, Taranto AG, Cortes V, Barbosa LA, Wach S, Taubert H, Simões CMO (2018) Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+ - ATPase inhibition. Biomedicine & Pharmacotherapy 107: 464-474 (DOI: 10.1016/j.biopha.2018.08.028)

Schneider NFZ, Cerella C, Lee JY, Mazumder A, Kim KR, de Carvalho A, Rodrigo M. Pádua RM, Munkert J, Kreis W, Kim KW, Christov C, Kim HJ, Dicato M, Han BW, Braga FC, Simões CMO, Diederich M (2018) Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-specific Cell Death. Frontiers in Pharmacology 9:70 (DOI:10.3389/fphar.2018.00070)

Schneider NFZ, Persich L, Rocha SC, Ramos ACP, Cortes VF, Silva IT, Munkert J, Pádua RM, Kreis W, Taranto AG, Barbosa LA, Braga FC, Simões CMO (2018) Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase. Biomed Pharmacother 97:684-696 (DOI:10.1016/j.biopha.2017.10.128)

Munkert J, Kreis W (2017) Herzglykoside und ihr Potenzial für die Tumortherapie. Deutsche Zeitschrift für Onkologie 49(03): 129-135

Munkert J, Santiago Franco M, Nolte E, Silva IT, Oliveira Castilho R, Melo Ottoni F, Schneider NFZ, Oliveira MC, Taubert H, Bauer W, Andrade SF, Alves RJ, Simões CMO, Braga FC, Kreis W, de Pádua RM (2017) Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture. Planta Medica 83: 1035-43 (DOI:10.1055/s-0043-109557)

Nolte E, Wach S, Silva IT, Lukat S, Ekici A B, Munkert J, Frieder Müller-Uri F, Kreis W, Simões CMO, Vera J, Wullich B, Taubert H, Lai X (2017) A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines. Oncotarget (DOI:10.18632/oncotarget.14644 )

Meitinger N, Munkert J, Pádua RM, Dias de Souza JF, Maid H, Bauer W, Braga FC, Kreis W (2016) The catalytic mechanism of the 3-ketosteroid isomerase of Digitalis lanata involves an intramolelcular proton transfer and the activity is not associated with the 3β-hydroxysteroid dehydrogenase activity. Tetrahedron Letters 57: 1567-1571 (DOI:10.1016/j.tetlet.2016.02.099)

Ernst M, Munkert J, Campa M, Malnoy M, Martens S, Müller-Uri F (2015) Steroid 5β-reductase from leaves of Vitis vinifera: molecular cloning, expression and modelling. Journal of Agriculture and Food Chemistry 63: 10112-10120 (DOI:10.1021/acs.jafc.5b04261)

Petersen J, Lanig H, Munkert J, Bauer P, Müller-Uri F, Kreis W (2015) Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics 2015 Oct 12:1-14 (DOI:10.1080/07391102.2015.1088797)

Munkert J, Costa C, Budeanu O, Petersen J, Bertolucci S, Fischer G, Müller-Uri F, Kreis W (2015) Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers. Plant Biology 17: 1113-1122 (DOI:10.1111/plb.12361)

Munkert J, Pollier J, Miettinen K, van Moerkercke A, Payne R, Mueller-Uri F, Burlat V, O'Connor S, Memelink J, Kreis W, Goosens A (2015) Iridoid Synthase Activity is Common among the Plant Progesterone 5β-Reductase Family. Molecular Plant 8: 136-152 (DOI: 10.1093/mp/ssu100)

Munkert J, Ernst M, Mueller-Uri F, Kreis W (2014) Identification and stress-induced expression of three 3β-hydroxysteroid dehydrogenases from Erysimum crepidifolium Rchb. and their putative role in cardenolide biosynthesis. Phytochemistry 100: 26-33

Munkert J, Bauer P, Burda E, Müller-Uri F, Kreis W (2011) Progesterone 5β-reductase of Erysimum crepidifolium: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant protein. Phytochemistry. 72: 1710-1717

Bauer P, Munkert J, Brydziun M, Burda E, Müller-Uri F, Gröger H, Muller YA, Kreis W (2010) Highly conserved progesterone 5β-reductase (P5βR) genes, from 5β-cardenolide-free and 5β-cardenolide-producing angiosperms. Phytochemistry. 71 (13): 1495-1505

Book chapter

Kreis W, Munkert J, Maia de Pádua R (2017) Biossíntese de metabólitos primários e secundários. In: Farmacognosia do Produto Natural ao Medicamento. Simões CMO, Schenkel EP, Mello JCP, Mentz LA, Petrovick PR. Artmed Editora Ltda. Capitulo 11, 147 - 166 (ISBN 978-85-8271-359-4)


Oliveira MC, Gomes ER, Pádua RM, Silva IT, Braga FC, Barros ALB, Leite EA, Gomes DA, Miranda MC, Munkert J, Frade ACM (2018) COMPOSIÇÃO FARMACÊUTICA LIPOSSOMAL CONTENDO SUBSTÂNCIAS BIOATIVAS CO-ENCAPSULADAS COM ATIVIDADE CITOTÓXICA E ANTITUMORAL. Instituto Nacional da Propriedade Industrial (Número de protocolo de Patente: BR 10 2018 069645-9)