Publications of Wolfgang Kreis

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Kreis W (2017) The Foxgloves (Digitalis) Revisited. Planta Medica 83: 962-76 (DOI:10.1055/s-0043-111240)

Munkert J, Santiago Franco M, Nolte E, Thaís Silva I, Oliveira Castilho R, Melo Ottoni F, Schneider NFZ, Oliveira MC, Taubert H, Bauer W, Andrade SF, Alves RJ, Simões CMO, Braga FC, Kreis W, de Pádua RM (2017) Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture. Planta Medica 83: 1035-43 (DOI:10.1055/s-0043-109557)

Schneider NFZ, Silva IT, Persich L, Carvalho A, Rocha SC, Marostica L, Ramos ACP, Taranto AG, Pádua RM, Kreis W, Barbosa LA, Braga FC, Simões CMO (2017) Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation. Mol Cell Biochem 428: 23-39 (DOI:10.1007/s11010-016-2914-8)

Nolte E, Wach S, Thais Silva I, Lukat S, Ekici A B, Munkert J, Frieder Müller-Uri F, Kreis W, Simões CMO, Vera J, Wullich B, Taubert H, Lai X (2017) A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines. Oncotarget 2017 Feb 14;8(7):11676-11691 (DOI:10.18632/oncotarget.14644)

Sahin S, Eulenburg V, Kreis W, Villman C, Pischetsrieder M (2016) Three-Step Test System for the Identification of Novel GABAA Receptor Modulating Food Plants. Plant Foods Hum Nutr. 2016 Dec, 71(4):355-360 (DOI: 10.1007/s11130-016-0566-1)

Pádua RM, Meitinger N, Hennemann M, Schebitz P, Waibel R, Löber S, Gmeiner P, Clark T, Kreis W (2016) Spontaneous butenolide ring formation of pregnane-21-O-malonyl hemiesters under mild reaction conditions is facilitated by the 14β-hydroxy group present in all natural cardenolides. Tetrahedron 72: 4556-4563 (DOI: 10.1016/j.tet.2016.06.024)

Yücesan B, Mohammed A, Eker İ, Sameeullah M, Demir-Ordu Ö, Cihangir C, Şahbaz N, Kaya Ö, Müller-Uri F, Kreis W, Gürel E (2016) In vitro propagation and cardenolide profiling of Digitalis ferruginea subsp. schischkinii, a medicinally important foxglove species with limited distribution in Northern Turkey. In Vitro Cellular & Developmental Biology - Plant 52: 322-329 (DOI:10.1007/s11627-016-9759-4)

Meitinger N, Munkert J, Pádua RM, Dias de Souza JF, Maid H, Bauer W, Braga FC, Kreis W (2016) The catalytic mechanism of the 3-ketosteroid isomerase of Digitalis lanata involves an intramolelcular proton transfer and the activity is not associated with the 3β-hydroxysteroid dehydrogenase activity. Tetrahedron Letters 57:1567-1571 (DOI:10.1016/j.tetlet.2016.02.099)

Eker İ, Yücesan B, Sameeullah M, Welß W, Müller-Uri F, Gürel E, Kreis W (2016) Phylogeny of Anatolian (Turkey) species in the Digitalis sect. Globiflorae (Plantaginaceae). Phytotaxa 244(3): 263-282 (DOI:10.11646/phytotaxa.244.3.3)

Rudolph K, Parthier C, Eggerer-Sieber C, Geiger D, Muller YA, Kreis W, Müller-Uri F (2016) Expression, crystallization and structure elucidation of γ-terpinene synthase from Thymus vulgaris . Acta Crystallographica F72:16-23 (DOI:10.1107/S2053230X15023043)

Petersen J, Lanig H, Munkert J, Bauer P, Müller-Uri F, Kreis W (2015) Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics 2015 Oct 12:1-14 [Epub ahead of print] (DOI:10.1080/07391102.2015.1088797)

Schneider NFZ, Geller FC, Persich L, Marostica LL, Pádua RM, Kreis W, Braga FC, Simões CM (2015) Inhibition of cell proliferation, invasion and migration by the cardenolides digitoxigenin monodigitoxoside and convallatoxin in human lung cancer cell line. Natural Product Research Aug 7: 1-5 [Epub ahead of print]; (DOI:10.1080/14786419.2015.1055265)

Nolte E, Sobel A, Wach S, Hertlein H, Ebert N, Müller-Uri F, Slany R, Taubert H, Wullich B, Kreis W (2015) The new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) efficiently suppresses cell growth in human leukemia and urologic tumor cell lines. Anticancer Research 35: 5271-5276

Munkert J, Costa C, Budeanu O, Petersen J, Bertolucci S, Fischer G, Müller-Uri F, Kreis W (2015) Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers. Plant Biology 17: 1113-1122 (DOI:10.1111/plb.12361)

Mohammed A, Yücesan B, Demir-Ordu Ö, Cihangir C, Eker İ, Kreis W, Gürel E (2015) In vitro regeneration and cardenolide determination of an endemic foxglove, Digitalis cariensis (Aegean Foxglove). In Vitro Cell.Dev.Biol.-Plant 51:438-444 (DOI:10.1007/s11627-015-9697-6)

Meitinger N, Geiger D, Augusto TW, Maia de Pádua R, Kreis W (2015) Purification of Δ(5)-3-ketosteroid isomerase from Digitalis lanata. Phytochemistry 109:6-13. (DOI: 10.1016/j.phytochem.2014.10.025)

Munkert J, Pollier J, Miettinen K, van Moerkercke A, Payne R, Mueller-Uri F, Burlat V, O'Connor S, Memelink J, Kreis W, Goosens A (2015) Iridoid Synthase Activity is Common among the Plant Progesterone 5β-Reductase Family. Molecular Plant 8: 136-152 (DOI: 10.1093/mp/ssu100)

Kreis W, Haug B, Yücesan B (2014) Somaclonal variation of cardenolide content in Heywood's foxglove, a source for the antiviral cardenolide glucoevatromonoside, regenerated from permanent shoot culture and callus. In Vitro Cell.Dev.Biol.-Plant 51:35-41 (DOI: 10.1007/s11627k-014-9642-0)

Rudolph K, Bauer P, Schmid B, Mueller-Uri F, Kreis W (2014) Truncation of N-terminal regions of Digitalis lanata progesterone 5β-reductase alters catalytic efficiency and substrate preference. Biochimie 101: 31-38

Munkert J, Ernst M, Mueller-Uri F, Kreis W (2014) Identification and stress-induced expression of three 3β-hydroxysteroid dehydrogenases from Erysimum crepidifolium Rchb. and their putative role in cardenolide biosynthesis. Phytochemistry 100: 26-33

Loebers A, Müller-Uri F, Kreis W (2014) A young root-specific gene (ArMY2) from horseradish encoding a MYR II myrosinase with kinetic perference for the root-specific glucosinolate gluconasturtiin. Phytochemistry. 99: 26-35

Yücesan B, Müller-Uri F, Kreis W, Gürel E (2014) Cardenolide estimation in callus-mediated regenerants of Digitalis lamarckii Ivanina (dwarf foxglove). In Vitro Cellular & Developmental Biology - Plant 50: 137-142

Pádua RM, Meitinger N, Dias de Souza JF, Waibel R, Gmeiner P, Braga FC, Kreis W (2012) Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W.1.4). Steroids 77: 1373-1380

Durchschein K, Wallner S, Macheroux P, Schwab W, Winkler T, Kreis W, Faber K (2012) Nicotinamide-Dependent Ene Reductases as Alternative Biocatalysts for the Reduction of Activated Alkenes. Eur. J. Org. Chem. 2012 (26): 4963-4968

Bauer P, Rudolph K, Müller-Uri F, Kreis W (2012) Vein Patterning 1-encoded progesterone 5β-reductase: Activity-guided improvement of catalytic efficiency. Phytochemistry. 77: 53-59

Bauer P, Kreis W (2011) Curcumin in der Krebstherapie. Deutsche Zeitschrift für Onkologie 41:144-149

Bertol JW, Rigotto C, de Pádua RM, Kreis W, Barardi CR, Braga FC, Simões CM (2011) Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata. Antiviral Res. 92: 73-80 (online)

Munkert J, Bauer P, Burda E, Müller-Uri F, Kreis W (2011) Progesterone 5β-reductase of Erysimum crepidifolium: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant protein. Phytochemistry. 72: 1710-1717

Baumgertel A, Loebers A, Kreis W (2010) Buckwheat as a Source for the Herbal Drug Fagopyri herba: Rutin Content and Activity of Flavonoid-Degrading Enzymes during Plant Development. Europ. J. Plant Sc. Biotech. 4 (Special Issue 1): 82-86

Bauer P, Munkert J, Brydziun M, Burda E, Müller-Uri F, Gröger H, Muller YA, Kreis W (2010) Highly conserved progesterone 5β-reductase (P5βR) genes, from 5β-cardenolide-free and 5β-cardenolide-producing angiosperms. Phytochemistry. 71 (13): 1495-1505

Ernst M, Pádua RM, Herl V, Müller-Uri F, Kreis W (2010) Expression of 3β-HSD und P5βR, genes encoding for Δ5-3β-hydroxisteroid dehydrogenase (3β-HSD) and progesterone 5β-reductase (P5βR) in leaves and cell cultures of Digitalis lanata Ehrh. Planta Med. 76 (9): 923-927

Schebitz P, Nothdurft L, Hensel A, Müller-Uri F, Kreis W (2010) Norcholanic acids as substrates for recombinant enzymes in cardenolide biosynthesis in Digitalis lanata Ehrh. Tetrahedron Letters. 51: 367-70

Müller-Uri F, Kreis W (2010) Recent Advances in Cardenolide Research. Buletinul Academiei de Stiinte a Moldovei. 2 (311): 45-52

Burda E, Krausser M, Fischer G, Hummel W, Müller-Uri F, Kreis W, Gröger H (2009) Recombinant Δ4,5-steroid 5β-reductases as biocatalysts for the reduction of activated C=C-double bonds in acyclic and monocyclic molecules. Advanced Synthesis & Catalysis 351: 2787-90

Kreis W (2009) Sekundäre Pflanzenstoffe und Krebs. Deutsche Zeitschrift für Onkologie. 41: 100-8

Coniglio M, Kreis W (2009) Immobilization of flavonol 3-O-β-heterodisaccharidase on porous glass and production of rutinose from rutin. Planta Med. 75: 1459-61

Herl V, Fischer G, Reva VA, Stiebritz M, Muller YA, Müller-Uri F, Kreis W (2009) The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Δ4,5-steroid 5β-reductase activity in Arabidopsis thaliana L. Biochimie 91 (4): 517-25

Herl V, Albach DC, Müller-Uri F, Bräuchler C, Heubl G, Kreis W (2008) Using progesterone 5β-reductase, a gene encoding a key enzyme in the cardenolide biosynthesis, to infer the phylogeny of the genus Digitalis. Plant Syst. Evol. 271: 65-78

Kreis W, Christmann A (2008) Burren - Rocks and Loughs. Student und Praktikant. 4: 80-84

Thorn A, Egerer-Sieber C, Jäger CM, Herl V, Müller-Uri F, Kreis W, Muller YA (2008) The crystal structure of progesterone 5β-reductase from Digitalis lanata defines a novel class of short-chain dehydrogenases/reductases. J. Biol. Chem. 283: 17260-69

Pádua RM, Waibel R, Kuate SP, Schebitz PK, Hahn S, Gmeiner P, Kreis W (2008) A simple chemical method for synthesizing malonyl hemiesters of 21-hydroxy-pregnanes, potential intermediates in cardenolide biosynthesis. Steroids. 73: 458-65

Kuate SP, Pádua RM, Eisenbeiss WF, Kreis W (2008) Purification and characterization of malonyl-coenzyme A: 21-hydroxypregnane 21-O-malonyltransferase (Dp21MaT) from leaves of Digitalis purpurea L. Phytochemistry. 69: 619-26

Kuate SP, Pádua RM, Poumale HMP, Kreis W (2007) Synthesis of a putative substrate for malonyl-coenzyme A: 21-hydroxypregnane 21-O-malonyltransferase and development of an HPLC method for the quantification of the enzyme reaction. J. Chromatogr. 860: 195-201

Herl V, Frankenstein J, Müller-Uri F, Meitinger N, Kreis W (2007) Δ5-3β-hydroxysteroid dehydrogenase (3β-HSD) from Digitalis lanata Ehrh. Heterologous expression and characterisation of the recombinant enzyme. Planta Med. 73: 704-10

Schaller F, Kreis W (2006) Cardenolide genin pattern in Isoplexis plants and shoot cultures. Planta Med. 72: 1149-56

Herl V, Fischer G, Bötsch R, Müller-Uri F, Kreis W (2006) Molecular cloning and expression of progesterone 5β-reductase (5β-POR) from Isoplexis canariensis. Planta Med. 72: 1163-65

Egerer-Sieber C, Herl V, Müller-Uri F, Kreis W, Muller YA (2006) Crystallization and preliminary crystallographic analysis of selenomethionine-labelled progesterone 5β-reductase from Digitalis lanata Ehrh. Acta Cryst. 62 (Pt3): 186-188

Herl V, Fischer G, Müller-Uri F, Kreis W (2006) Molecular cloning and heterologous expression of progesterone 5β-reductase from Digitalis lanata Ehrh. Phytochemistry. 67: 225-231

Nüßlein B, Kreis W (2005) Purification and Characterization of a Cynaroside 7-O-β-D-Glucosidase from Cynarae scolymi folium. ISHS Acta Horticulture: 681. IV International Congress on Artichoke

Sußner U, Abel G, Schulte R, Kreis W (2004) Isolation and characterisation of a cystein protease (phytolacain G) from Phytolacca americana roots. Planta Med. 70: 881-1014

Baumgertel A, Grimm R, Eisenbeiss W, Kreis W (2003) Purification and charakterization of flavonol 3-O-β-heterodisaccharidase from the dried herb of Fagopyrum esculentum Moench. Phytochemistry. 64: 411-18

Kreis W (2003) Pharmakotherapie von ADHD – Biologische Grundlagen und Grenzen. Z. f. Nervenheilkunde. 22: 427-85

Nüsslein B, Kurzmann M, Bauer R and Kreis W (2000) Enzymatic Degradation of Cichoric Acid in Echinacea purpurea Preparations. J. Nat. Prod. 63: 1615-18

Hornberger M, Böttigheimer U, Hillier-Kaiser A, Kreis W (2000) Purification and characterisation of the cardenolide-specific ß-glucohydrolase CGH II from Digitalis lanata leaves. Plant. Physiol. Biochem. 38: 929-36

Terada Y, Misoi R, Watanabe N, Hornberger M, Kreis W (2000) Structure-Specificity of Cardiac Glycosides as a Substrate for Glucohydrolase II. Chem. Pharm. Bull. 48: 349-52

Kreis W, Sußner U, Nüßlein B (2000) Reinigung und Charakterisierung einer Polyphenoloxidase aus der Arzneidroge Echinaceae purpurea herba (Sonnenhutkraut). Journal of Applied Botany - Angewandte Botanik. 74: 106-12

Nüßlein B, Kreis W (2000) Reinigung einer Cynarosid-7-O-D-glucosidase aus der Arzneidroge Cynarae folium (Artischockenblätter). Journal of Applied Botany - Angewandte Botanik. 74: 113-18

Kreis W, Stoll G (2000) Biotechnologie für Pharmazeuten. Deutsche Apotheker Zeitung. 140: 1300-07

Eisenbeiss M, Kreis W, Reinhard E (1999) Cardenolide biosynthesis in light- and dark-grown Digitalis lanata shoot cultures. Plant Physiol. Biochem. 37: 13-23

Braga FC, Kreis W, Braga de Oliveira A (1998) Effect of Digitalis lanata matrix composition on the lanatoside C partition coefficient and its consequence on rotation locular counter-current chromatography efficiency. J. Chromatogr. A. 822: 37-44

Hensel A, Schmidgall J, Kreis W (1998) The plant cell wall - a potential source for pharmacologically active polysaccharides. Pharmac. Acta Helv. 73: 37-43

Kreis W, Hensel A, Stuhlemmer U (1998) Cardenolide Biosynthesis in Foxglove. Planta Med. 64: 491-99

Theurer C, Kreis W, Reinhard E (1998) Effects of digitoxigenin, digoxigenin, and various cardiac glycosides on cardenolide accumulation in shoot cultures of Digitalis lanata Ehrh. Planta Med. 64: 705-10

Luta M, Hensel A, Kreis W (1998) Synthesis of cardenolide glycosides and putative biosynthesis precursors of cardenolide glycosides. Steroids. 63: 44-49

Braga FC, Kreis W, Récio RA, de Oliveira AB (1997) Avaliacao quantitativa de cardenolídeos no cultivar experimental de Digitalis lanata do macico do Itatiaia e perspectivas de seu emprego industrial. Química Nova. 20: 481-85

Kreis W (1997) Biotechnologische Optimierung der Wirkstoffproduktion bei Arznei- und Gewürzpflanzen. Z. Arzn.Gew.pfl. 2: 15-23

Hensel A, Schmidgall J, Kreis W (1997) Extracellular polysaccharides produced by suspension-cultured cells from Digitalis lanata. Planta Med. 63: 441-45

Hensel A, Kreis W (1997) GLC-MS investigations on cardenolide genins. Pharm. Acta Helv. 72: 243-46

Braga FC, Kreis W, Récio RA, de Oliveira AB (1997) Variation of cardenolides with growth in a Digitalis lanata Brazilian cultivar. Phytochemistry. 45: 473-76

Haussmann W, Kreis W, Stuhlemmer U, Reinhard E (1997) Effects of various pregnanes and two 23-nor-5-cholenic acids on cardenolide accumulation in cell and organ cultures of Digitalis lanata EHRH. Planta Med. 63: 446-53

May U, Kreis W (1997) Purification and characterization of the cardenolide-specific b-glucohydrolase CGH I from Digitalis lanata EHRH. leaves. Plant Physiol. Biochem. 35: 523-32

Milek F, Reinhard E, Kreis W (1997) Influence of precursors and inhibitors of the sterol pathway on sterol and cardenolide metabolism in Digitalis lanata EHRH. Plant Physiol. Biochem. 35: 111-21

Castro Braga F, Kreis W, Braga de Oliveira A (1996) Isolation of cardenolides from a Brazilian cultivar of Digitalis lanata by rotation locular counter-current chromatography. J. Chromatogr. 756: 287-91

Sutor R, Kreis W (1996) Partial purification and characterization of the cell-wall-associated lanatoside 15’-O-acetyltransferase from Digitalis lanata suspension cultures. Plant Physiol. Biochem. 34: 763-70

Stuhlemmer U, Kreis W (1996) Does Malonyl coenzyme A:Hydroxypregnane 21-Hydroxymalonyltransferase catalyze the first step in butenolide ring formation? Tetrahedron Lett. 37: 2221-24

Schaller F, Kreis W (1996) Clonal propagation of Isoplexis canariensis (L.) Lindl. ex. G. Don. Planta Med. 62: 450-52

Stuhlemmer U, Kreis W (1996) Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata. Plant Physiol. Biochem. 34: 85-91

Theurer C, Treumann, H-J, Faust T, May U, Kreis W (1994) Glycosylation in cardenolide biosynthesis. Plant Cell Tissue and Organ Culture 38: 327-35

Faust T, Theurer C, Eger K, Kreis W (1994) Synthesis of uridine 5'-(α-D-fucopyranosyl diphosphate) and (digitoxigenin-3β-yl)-β-D-fucopyranoside and enzymatic β-D-fucosylation of cardenolide genins in Digitalis lanata. Bioorg. Chem. 22: 140-49

Stuhlemmer U, Haussmann W, Milek F, Kreis W, Reinhard E (1993) 3α-Hydroxysteroid-5β-Oxidoreductase in Tissue Cultures of Digitalis lanata. Z. Naturforsch. C. 48: 713-21

Christmann J, Kreis W, Reinhard E (1993) Uptake, transport and storage of cardenolides in foxglove. cardenolide sinks and occurence cardenolides in the sieve tubes of Digitalis lanata. Botanica Acta. 106: 419-27

Kreis W (1993) Arzneistoffe aus pflanzlichen Zell- und Gewebekulturen, Möglichkeiten und Grenzen. Deutsche Apotheker Zeitung 133.Jahrg. Nr.15: 1333-56

Stuhlemmer U, Kreis W, Eisenbeiss M, Reinhard E (1993) Cardiac glycosides in partly submerged shoots of Digitalis lanata. Planta Med. 59: 539-45

Maier R, Carle R, Kreis W, Reinhard E (1993) Purification and characterization of a flavone-7-O-glucoside-specific glucosidase from ligulate florets of Chamomilla recutita. Planta Med. 59:436-41

Kreis W, Hoelz H, Sutor R, Reinhard E (1993) Cellular organization of cardenolide biotransformation in Digitalis grandiflora. Planta. 191:246-51

Gaus H-J, Treumann H-J, Kreis W, Bayer E (1993) Separation of cardiac glycosides by micellary electrokinetic capillary electrophoresis. J. Chromatogr. 635: 319-22

Sutor R, Kreis W, Hoelz H, Reinhard E (1993) Acetyl coenzyme A:digitoxin 15'-O-acetyltransferase from Digitalis plants and suspension cultures. Phytochemistry. 32: 569-73

Blom TJM, Kreis W, Van Iren F, Libbenga KR (1992) A non-invasive method for the routine-estimation of fresh weight of cells grown in batch suspension cultures. Plant Cell Rep. 11: 146-49

Krombholz R, Mersinger R, Kreis W, Reinhard E (1992) Production of forskolin by axenic Coleus forskohlii roots cultivated in shake flasks and 20-l glass jar bioreactors. Planta Med. 58: 328-33

Kreis W, Reinhard E (1992) 12β-Hydroxylation of digitoxin by suspension-cultured Digitalis lanata cells. Production of digoxin in 20-litre and 300-litre airlift bioreactors. J. Biotechnol. 26: 257-73

Hoelz H, Kreis W, Haug B, Reinhard E (1992) Storage of cardiac glycosides in vacuoles of Digitalis lanata mesophyll cells. Phytochemistry. 31: 1167-71

Kreis W, Fulzele D, Hoelz H, Val J, Reinhard E (1992) Production of cardenolides by Digitalis cell cultures - models and process options. In: Oono K, Hirabayashi T, Kikuchi S, Handa H, Kajiwara K (Hrsg) Plant Tissue Culture and Gene Manipulation for Breeding and Formation of Phytochemicals, National Institute of Agrobiological resources (NIAR), Tsukuba, 335-54

Kreis W, Hölz H (1991) Zellulärer Transport und Speicherung von Naturstoffen. Die Bedeutung der Vakuole im pflanzlichen Sekundärstoffwechsel. Naturwiss. Rundschau 44: 463-70

Maier R, Kreis W, Carle R, Reinhard E (1991) A Flavone-Glucoside-Cleaving β-Glucosidase from Chamomilla recutita. Planta Med. 57: 297-98

Baumann Th, Kreis W, Mehrle W, Hampp R, Reinhard E (1991) Elektrofusion von Protoplasten aus Digitalis lanata EHRH. und Digitalis purpurea L. Suspensionskulturen unter Mikrogravitation. Vergleich der enzymatischen Eigenschaften der regenerierten Zellinien. In: Tagungsband DARA Symposium 1991, Statusseminar Forschung unter Weltraumbedingungen, 4.-6.3.1991, Aachen

Seidel S, Kreis W, Reinhard E (1990) Δ5-3β-hydroxysteroid dehydrogenase Δ5/Δ4-ketosteroid isomerase (3β-HSD), a possible enzyme of cardiac glycoside biosynthesis, in cell cultures and plants of Digitalis lanata Ehrh. Plant Cell Rep. 8: 621-24

Kreis W, Reinhard E (1990) Two-stage cultivation of Digitalis lanata cells: Semicontinuous production of deacetyllanatoside C in 20-litre airlift bioreactors. J. Biotechnol. 16: 123-36

Sutor R, Hoelz H, Kreis W (1990) Lanatoside 15'-O-acetylesterase from Digitalis (Scrophulariaceae) plants and cell cultures. J. Plant Physiol. 136: 289-94

Kreis W, May U (1990) Cardenolide glucosyltransferases and glucohydrolases in leaves and cell cultures of three Digitalis (Scrophulariaceae) species. J. Plant Physiol. 136: 247-52

Kreis W, Hoelz H, May U, Reinhard E (1990) Storage of cardenolides in Digitalis lanata cells. Effect of dimethyl sulfoxide (DMSO) on cardenolide uptake and release. Plant Cell, Tissue and Organ Culture. 20: 191-99

Baumann T, Kreis W, Mehrle W, Hampp R, Reinhard E (1990) Regeneration and characterization of protoplast-derived cell lines from Digitalis lanata Ehrh. and Digitalis purpurea L. suspension cultures after electrofusion under microgravity conditions. In: Proceedings of the 4th Eurpean symposium on life sciences research in space, ESA Publications Div, ESTEC, Noordwijk, 405-10

Kreis W, Reinhard E (1990) Production of deacetyllanatoside C by Digitalis lanata cell cultures. In: Nijkamp HJJ, Van der Plaas LHW, Van Aartrijk J (Hrsg) Progress in plant cellular and molecular biology, Kluwer Academic Publishers, Dordrech Boston London, 706-11

Reinhard E, Kreis W (1989) Kultivierung von pflanzlichen Zellkulturen in Bioreaktoren. BioEngineering. 5: 135-36

Kreis W, Reinhard E (1989) The production of secondary metabolites by plant cells cultivated in bioreactors. Planta Med. 55: 409-16

Kreis W, Zhu W, Reinhard E (1989) 12β-hydroxylation of digitoxin by Digitalis lanata cells. Production of deacetyllanatoside C in a 20-L airlift bioreactor. Biotechnol. Lett. 11: 325-30

Reinhard E, Kreis W, Barthlen U, Helmbold U (1989) Semicontinuous Cultivation of Digitalis lanata cells. Production of β-methyldigoxin in a 300-L airlift bioreactor. Biotechnol. Bioengin. 34: 502-08

Kreis W, Reinhard E (1988) 12β-hydroxylation of digitoxin by suspension-cultured Digitalis lanata cells. Production of deacetyllanatoside C using a two-stage culture method. Planta Med. 54: 143-148

Kreis W, Reinhard E (1987) Selective uptake and vacuolar storage of primary cardiac glycosides by suspension-cultured Digitalis lanata cells. J. Plant Physiol. 128: 311-26

Kreis W, May U, Reinhard E (1987) Subcellular localization of primary and secondary cardiac glycosides and the related 16'-O-glucosyltransferase in cell suspension cultures of Digitalis lanata. In: Marin B (Hrsg) Plant Vacuoles. Their importance for plant cell compartmentation and their application in biotechnology, Plenum Publ, London, 425-33

Kreis W, Reinhard E (1986) Highly efficient 12β-hydroxylation of digitoxin in Digitalis lanata cell suspensions using a two-staged culture method. Planta Med. 1986: 418-19

Kreis W, May U, Reinhard E (1986) UDP-glucose:digitoxin 16'-O-glucosyltransferase from suspension-cultured Digitalis lanata cells. Plant Cell Rep. 5: 442-45

Kreis W, Reinhard E (1985) Rapid isolation of vacuoles from suspension-cultured Digitalis lanata cells. J. Plant Physiol. 121: 385-90

Endress R, Jäger A, Kreis W (1984) Catecholamine biosynthesis dependent on the dark in betacyanin-forming Portulaca callus. J. Plant Physiol. 115: 291-95

 

Book chapter

Kreis W, Munkert J, Maia de Pádua R (2017) Biossíntese de metabólitos primários e secundários. In: Farmacognosia do Produto Natural ao Medicamento. Simões CMO, Schenkel EP, Mello JCP, Mentz LA, Petrovick PR. Artmed Editora Ltda. Capitulo 11, 147 - 166 (ISBN 978-85-8271-359-4)

Kreis W (2016) Lektine: Potentielle Quellen und Anwendungen In: Scheer R, Alban S, Becker H, Beer A-M, Blaschek W, Kreis W, Matthes H, Schilcher H, Spahn G, Stange R (Hrsg.) Die Mistel in der Tumortherapie 4, Aktueller Stand der Forschung und klinische Anwendung, KVC-Verlag - Karl und Veronica Carstens-Stiftung, Essen, 43-60

Dingermann T, Kreis W, Nieber K, Rimpler H, Zündorf I (2016) Reinhard Pharmazeutische Biologie, Grundlagen und Humanbiologie, 8. Aufl., Wissenschaftliche Verlagsgesellschaft, Stuttgart

Kreis W, (2015) Enzyme bei der Gewinnung von Drogen und der Herstellung von Phytopharmaka. In: Hänsel R, Sticher O: Pharmakognosie – Phytopharmazie. 10. Aufl., Wissenschaftliche Verlagsgesellschaft Stuttgart, 212-17

Kreis W, Matern U (2015) Prinzipien der Biosynthese pflanzlicher Naturstoffe. In: Hänsel R, Sticher O: Pharmakognosie – Phytopharmazie. 10. Aufl., Wissenschaftliche Verlagsgesellschaft Stuttgart, 3-31

Kreis W, Müller-Uri F (2013) Cardenolide aglycone formation in Digitalis. Chapter 29, pp.425-438. In: Bach TJ, Rohmer M (eds.) Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches, DOI 10.1007/978-1-4614-4063-5_29, Springer Science+Business Media New York

Clemente ES, Müller-Uri F, Nebauer SG, Segura J, Kreis W, and Arrillaga I (2011) Digitalis, Chapter 5, pp. 73-112. In: Kole C (ed.), Wild Crop Relatives: Genomic and Breeding Resources, Plantation and Ornamental Crops, DOI 10.1007/978-3-642-21201-7_5, Springer-Verlag Berlin Heidelberg

Kreis W, Müller-Uri F (2010) Biochemistry of sterols, cardiac glycosides, brassinosteroids, phytoecdysteroids and steroid saponins. In: Wink, M. (ed.) Biochemistry of Plant Secondary Metabolism. Annual Review Plant Vol. 40: 304-363 CRC Press, Sheffield

Kreis W (2010) Enzyme bei der Gewinnung von Drogen und der Herstellung von Phytopharmaka. In: Hänsel R, Sticher O: Pharmakognosie – Phytopharmazie. Springer-Verlag Berlin Heidelberg New York, 273-79

Kreis W (2010) Prinzipien des Sekundärstoffwechsels. In: Hänsel R, Sticher O: Pharmakognosie – Phytopharmazie. Springer-Verlag Berlin Heidelberg New York,   3-27

Kreis W (2009) Fortschritte bei der Strukturaufklärung von Inhaltsstoffen der Mistel In: Scheer R, Alban S, Becker H, Holzgrabe U, Kemper F H, Kreis W, Matthes H, Schilcher H (Hrsg.) Die Mistel in der Tumortherapie 2, Aktueller Stand der Forschung und klinische Anwendung, KVC-Verlag - Karl und Veronica Carstens-Stiftung, Essen, 17-29

Dingermann T, Kreis W, Rimpler H, Zündorf I, (2009) Reinhard Pharmazeutischen Biologie 1, Grundlagen für Studium und Praxis, 7. Aufl., Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart

Kreis W (2007) Enzyme bei der Gewinnung von Drogen und der Herstellung von Phytopharmaka. In: Hänsel R, Sticher O: Pharmakognosie – Phytopharmazie, 9. Aufl., Springer-Verlag Berlin Heidelberg New York, 3-29

Kreis W (2007) Prinzipien des Sekundärstoffwechsels. In: Hänsel R, Sticher O: Pharmakognosie – Phytopharmazie. 9. Aufl., Springer-Verlag Berlin Heidelberg New York, 274-79

Kreis W (2007) Enzyme bei der Gewinnung von Drogen und der Herstellung von Phytopharmaka. In: Hänsel R, Sticher O: Pharmakognosie – Phytopharmazie. 8. Aufl., Springer-Verlag Berlin Heidelberg New York, 3-30

Kreis W (2007) Prinzipien des Sekundärstoffwechsels. In: Hänsel R, Sticher O: Pharmakognosie – Phytopharmazie. 8. Aufl., Springer-Verlag Berlin Heidelberg New York, 285-91

Kreis W (2007) In vitro culturing techniques of medicinal plants. In: Kayser O, Quax WJ (Hrsg.) Medicinal Plant Biotechnology. From Basic Research to Industrial Applications. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Kreis W (2003) Plant cell, tissue and organ cultures as tools for elucidating biosynthetic pathways. In: Sprecher E (Hrsg.), Caesar W. Society for Medicinal Plant Research 50 Years 1953-2003. A Jubilee Edition. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart

Kreis W, Baron D, Stoll G (2001) Biotechnologie der Arzneistoffe. Deutscher Apotheker Verlag, Stuttgart

Reinhard E, Dingermann T, Kreis W, Rimpler H (2001) Lehrbuch der Pharmazeutischen Biologie, 6. Aufl., Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart

Gershenzon J, Kreis W (1999) Biochemistry of terpenoids: monoterpenes, sesquiterpenes, diterpenes, sterols, cardiac glycosides and steroid saponins. In: Wink M (Hrsg) Biochemistry of Plant Secondary Metabolism, Sheffield Academic Press, Sheffield, 222-99

Kreis W (1995) Morphologie, Histologie und Anatomie des Kormus, In: Reinhard E, Kreis W, Rimpler H. Lehrbuch der Pharmazeutischen Biologie 1, 5. Aufl., Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 473-547

Theurer C, Kreis W (1993) Xysmalobium, In: Hänsel R, Keller K, Rimpler H (Hrsg) Hagers Handbuch der pharmazeutischen Praxis. Drogen, 5. Auflage. Springer-Verlag, Berlin Heidelberg New York

Kreis W (1993) Hydrastis, In: Hänsel R, Keller K, Rimpler H (Hrsg) Hagers Handbuch der pharmazeutischen Praxis. Drogen, 5. Auflage. Springer-Verlag, Berlin Heidelberg New York

Kreis W (1993) Jateorhiza, In: Hänsel R, Keller K, Rimpler H (Hrsg) Hagers Handbuch der pharmazeutischen Praxis. Drogen, 5. Auflage. Springer-Verlag, Berlin Heidelberg New York

Kreis W (1993) Eschscholzia, In: Hänsel R, Keller K, Rimpler H (Hrsg) Hagers Handbuch der pharmazeutischen Praxis. Drogen, 5. Auflage. Springer-Verlag, Berlin Heidelberg New York

Kreis W (1992) Dicentra, In: Hänsel R, Keller K, Rimpler H (Hrsg) Hagers Handbuch der pharmazeutischen Praxis. Drogen, 5. Auflage. Springer-Verlag, Berlin Heidelberg New York

Kreis W (1992) Corydalis, In: Hänsel R, Keller K, Rimpler H (Hrsg) Hagers Handbuch der pharmazeutischen Praxis. Drogen, 5. Auflage. Springer-Verlag, Berlin Heidelberg New York, 1013-27

Kreis W (1992) Chondodendron, In: Hänsel R, Keller K, Rimpler H (Hrsg) Hagers Handbuch der pharmazeutischen Praxis. Drogen, 5. Auflage. Springer-Verlag, Berlin Heidelberg New York, 852-58

Kreis W (1992) Cephaelis, In: Hänsel R, Keller K, Rimpler H (Hrsg) Hagers Handbuch der pharmazeutischen Praxis. Drogen, 5. Auflage. Springer-Verlag, Berlin Heidelberg New York, 771-88

Kreis W (1992) Buxus, In: Hänsel R, Keller K, Rimpler H (Hrsg) Hagers Handbuch der pharmazeutischen Praxis. Drogen, 5. Auflage. Springer-Verlag, Berlin Heidelberg New York,  588-94

Kreis W (1992) Berberis, In: Hänsel R, Keller K, Rimpler H (Hrsg) Hagers Handbuch der pharmazeutischen Praxis. Drogen, 5. Auflage. Springer-Verlag, Berlin Heidelberg New York,  480-97